Do you have kidney problems?

Purpose of the study

This study’s purpose is to find out how well the investigational study medication works in adults living with a genetic form of kidney disease.

About this study and about APOL1-mediated kidney disease

This study is looking for adults with APOL1-mediated kidney disease. This type of kidney disease can run in the family and is related to a substance in the body called the APOL1 protein.

We all have the APOL1 protein; however, some people have differences in their DNA (the genetic material in our body that carries information about how our body works) which means that they carry a changed type of APOL1 protein, known as a variant.

People with APOL1 variants have a higher risk of chronic kidney disease, but it is still not known how the variants cause kidney disease.

Several thousand years ago, APOL1 variant genes evolved in people who lived in Western and Central Africa to protect them from a parasitic disease known as African sleeping sickness.

This means that variants of APOL1 are more likely to occur in people of African descent, including people who identify as African, Black, Caribbean, Sub-Saharan African and Latin American (Cuban, Mexican, Puerto Rican, or South or Central American).

If you think that your kidney problems may be related to a genetic form of kidney disease, consider joining this research study.

This study has been approved by an Ethics Committee – the committee responsible for ensuring that patients in clinical studies are protected.

Who may participate in this study?

You may qualify for this research study, if the following applies to you:

• You are between 18 and 65 years old
• You have kidney problems not caused by diabetes

There are other eligibility requirements. A final decision on whether this research study might be a good fit for you will be made after you have completed the online and phone questionnaires and spoken with the study doctor at the research site. The study doctor will explain the benefits and risks of participation in this research study. Participation is voluntary and you can choose to stop participating at any time.

Reimbursement

If you qualify and choose to join the research study, you will receive all study-related care at no cost. This includes the investigational study medication and may include reimbursement for travel costs associated with visits to your study doctor’s office. There might be also the option of remote visits in some areas. Additional information will be provided by the study doctor.

Information under Article 13 and 14 GDPR and Summary of the Essentials of The Joint Controllership Agreement can be found here.